Gene Variant Detail

Gene CTNNB1
Variant W25_H36del
Impact List deletion
Protein Effect gain of function - predicted
Gene Variant Descriptions CTNNB1 W25_H36del results in the deletion of twelve amino acids in the Ctnnb1 protein from amino acids 25 to 36 (UniProt.org). W25_H36del is predicted to confer a gain of function to the Ctnnb1 protein as demonstrated by nuclear accumulation of Ctnnb1 (PMID: 17011185).
Associated Drug Resistance

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Transcript NM_001098210
gDNA chr3:g.41224586_41224621del36
cDNA c.74_109del36
Protein p.W25_H36del12
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_005264886 chr3:g.41224586_41224621del36 c.74_109del36 p.W25_H36del12 RefSeq GRCh38/hg38
NM_001904 chr3:g.41224586_41224621del36 c.74_109del36 p.W25_H36del12 RefSeq GRCh38/hg38
NM_001098210 chr3:g.41224586_41224621del36 c.74_109del36 p.W25_H36del12 RefSeq GRCh38/hg38
NM_001098209 chr3:g.41224586_41224621del36 c.74_109del36 p.W25_H36del12 RefSeq GRCh38/hg38
XM_006712985 chr3:g.41224586_41224621del36 c.74_109del36 p.W25_H36del12 RefSeq GRCh38/hg38
XM_006712984 chr3:g.41224606_41224641del36 c.73_108del36 p.D25_A36del12 RefSeq GRCh38/hg38
XM_006712983 chr3:g.41224606_41224641del36 c.73_108del36 p.D25_A36del12 RefSeq GRCh38/hg38
XM_017005738 chr3:g.41224586_41224621del36 c.74_109del36 p.W25_H36del12 RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
CTNNB1 W25_H36del gain of function - predicted
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References