Missing content? – Request curation!
Request curation for specific Genes, variants, or PubMed publications.
Have questions, comments or suggestions? - Let us know!
Email us at : firstname.lastname@example.org
|Variant||KMT2A - EP300|
|Gene Variant Descriptions||KMT2A-EP300 results from the fusion of KMT2A and EP300 (PMID: 20980053). KMT2A-EP300 has been identified in acute myeloid leukemia (PMID: 20980053), but not been biochemically characterized and therefore, the effect on protein function is unknown (PubMed, Jan 2022).|
|Associated Drug Resistance|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|KMT2A - EP300||acute myeloid leukemia||sensitive||MI-503||Preclinical - Patient cell culture||Actionable||In a preclinical study, MI-503 inhibited growth of a primary acute myeloid sample harboring KMT2A-EP300 in culture (PMID: 25817203).||25817203|
|Molecular Profile||Protein Effect||Treatment Approaches|
|KMT2A - EP300||unknown|