Gene Variant Detail

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Gene FLT3
Variant E598_Y599insDVDFREYE
Impact List insertion
Protein Effect gain of function - predicted
Gene Variant Descriptions FLT3 E598_Y599insDVDFREYE results in the insertion of eight amino acids in the Flt3 protein between amino acids 598 and 599 (UniProt.org). E598_Y599insDVDFREYE has not been biochemically characterized, but can be predicted to lead to activation of Flt3 based on the effects of other Flt3 internal tandem duplication (ITD) mutations (PMID: 12970773, PMID: 9737679, PMID: 11090077).
Associated Drug Resistance
Category Variants Paths

FLT3 mutant FLT3 exon14 FLT3 exon 14 ins FLT3 E598_Y599insDVDFREYE

FLT3 mutant FLT3 act mut FLT3 exon 14 ins FLT3 E598_Y599insDVDFREYE

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Transcript NM_004119.2
gDNA chr13:g.28034124_28034125insCTCATACTCCCTAAAGTCTACGTC
cDNA c.1794_1795insGACGTAGACTTTAGGGAGTATGAG
Protein p.E598_Y599insDVDFREYE
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119.2 chr13:g.28034124_28034125insCTCATACTCCCTAAAGTCTACGTC c.1794_1795insGACGTAGACTTTAGGGAGTATGAG p.E598_Y599insDVDFREYE RefSeq GRCh38/hg38
NM_004119 chr13:g.28034124_28034125insCTCATACTCCCTAAAGTCTACGTC c.1794_1795insGACGTAGACTTTAGGGAGTATGAG p.E598_Y599insDVDFREYE RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References