Gene Variant Detail

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Gene APC
Variant E853*
Impact List nonsense
Protein Effect loss of function - predicted
Gene Variant Descriptions APC E853* results in a premature truncation of the Apc protein at amino acid 853 of 2843 (UniProt.org). E853* has not been characterized, however, due to the effects of other truncation mutations downstream of E853 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
Associated Drug Resistance
Category Variants Paths

APC mutant APC inact mut APC E853*

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Transcript NM_000038.6
gDNA chr5:g.112838151G>T
cDNA c.2557G>T
Protein p.E853*
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001407450.1 chr5:g.112838151G>T c.2557G>T p.E853* RefSeq GRCh38/hg38
NM_001354906.1 chr5:g.112839000G>T c.2557G>T p.E853* RefSeq GRCh38/hg38
NM_000038.5 chr5:g.112838151G>T c.2557G>T p.E853* RefSeq GRCh38/hg38
NM_001407470.1 chr5:g.112839000G>T c.2557G>T p.E853* RefSeq GRCh38/hg38
NM_001354895.2 chr5:g.112838151G>T c.2557G>T p.E853* RefSeq GRCh38/hg38
NM_000038.6 chr5:g.112838151G>T c.2557G>T p.E853* RefSeq GRCh38/hg38
NM_000038 chr5:g.112838151G>T c.2557G>T p.E853* RefSeq GRCh38/hg38
NM_001354895.1 chr5:g.112838151G>T c.2557G>T p.E853* RefSeq GRCh38/hg38
NM_001127510.2 chr5:g.112838151G>T c.2557G>T p.E853* RefSeq GRCh38/hg38
NM_001127510.3 chr5:g.112838151G>T c.2557G>T p.E853* RefSeq GRCh38/hg38
NM_001127510 chr5:g.112838151G>T c.2557G>T p.E853* RefSeq GRCh38/hg38
NM_001354906.2 chr5:g.112839000G>T c.2557G>T p.E853* RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
APC E853* APC K1555* colorectal cancer sensitive TASIN-1 Preclinical - Cell line xenograft Actionable In a preclinical study, TASIN-1 efficiently inhibited survival of colorectal cancer cells harboring APC E853* and APC K1555* in culture and inhibited tumor growth in xenograft models (PMID: 27798265). 27798265
APC E853* APC T1556fs colorectal cancer resistant G007-LK Preclinical - Cell culture Actionable In a preclinical study, a colorectal cancer cell line harboring APC E853* and APC T1556fs (reported as APC T1556fs*3) demonstrated low levels of Tcf/LEF activity, and was resistant to treatment with G007-LK in culture (PMID: 28179481). 28179481
APC E853* APC T1556fs colorectal cancer resistant IWR-1 Preclinical - Cell culture Actionable In a preclinical study, a colorectal cancer cell line harboring APC E853* and APC T1556fs (reported as APC T1556fs*3) demonstrated low levels of Tcf/LEF activity, and was resistant to treatment with IWR-1 in culture (PMID: 28179481). 28179481
APC E853* APC T1556fs colorectal cancer resistant XAV939 Preclinical - Cell culture Actionable In a preclinical study, a colorectal cancer cell line harboring APC E853* and APC T1556fs (reported as APC T1556fs*3) demonstrated low levels of Tcf/LEF activity, and was resistant to treatment with XAV939 in culture (PMID: 28179481). 28179481
APC E853* APC T1556Nfs*3 colorectal cancer sensitive STP1002 Preclinical - Cell culture Actionable In a preclinical study, STP1002 inhibited Wnt/beta-catenin signaling and colony formation in a colorectal cancer cell line harboring APC E853* and APC T1556Nfs*3 in culture (PMID: 35849876). 35849876