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Gene FLT3
Variant F691I
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FLT3 F691I lies within the protein kinase domain of the Flt3 protein (PMID: 23430109). F691I has been demonstrated to promote secondary drug resistance in the context of FLT3 internal tandem duplication (FLT3-ITD) mutations (PMID: 23392356, PMID: 22409268), but has not been biochemically characterized and therefore, its effect on Flt3 protein function is unknown (PubMed, Sep 2022).
Associated Drug Resistance Y
Category Variants Paths

FLT3 mutant FLT3 exon17 FLT3 F691I

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Transcript NM_004119.2
gDNA chr13:g.28027224A>T
cDNA c.2071T>A
Protein p.F691I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119 chr13:g.28027224A>T c.2071T>A p.F691I RefSeq GRCh38/hg38
XM_011535015.2 chr13:g.28027167A>T c.2071T>A p.F691I RefSeq GRCh38/hg38
XM_011535015 chr13:g.28027167A>T c.2071T>A p.F691I RefSeq GRCh38/hg38
NM_004119.2 chr13:g.28027224A>T c.2071T>A p.F691I RefSeq GRCh38/hg38

Filtering

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  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
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  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References