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|Gene Variant Descriptions||ALK L1152P lies within the protein kinase domain of the Alk protein (UniProt.org). L1152P has been demonstrated to confer drug resistance in the context of ALK rearrangement in culture (PMID: 24675041), but has not been biochemically characterized and therefore, its effect on Alk protein function is unknown (PubMed, Sep 2022).|
|Associated Drug Resistance||Y|
|Category Variants Paths||
ALK mutant ALK L1152P
|Transcript||gDNA||cDNA||Protein||Source Database||Genome Build|
|Molecular Profile||Protein Effect||Treatment Approaches|
|EML4 - ALK ALK L1152P||Brigatinib|