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Gene TET2
Variant A1505T
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions TET2 A1505T lies within the catalytic domain of the Tet2 protein (PMID: 24315485). A1505T confers a loss of function to the Tet2 protein as demonstrated by the inability of Tet2 to inhibit cell proliferation, lack of WT1 binding and regulation of WT1 target genes, and reduced enzymatic conversion of 5mC (PMID: 25601757).
Associated Drug Resistance
Category Variants Paths

TET2 mutant TET2 inact mut TET2 A1505T

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Transcript NM_001127208.3
gDNA chr4:g.105272894G>A
cDNA c.4513G>A
Protein p.A1505T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001127208 chr4:g.105272894G>A c.4513G>A p.A1505T RefSeq GRCh38/hg38
XM_005263082 chr4:g.105272894G>A c.4513G>A p.A1505T RefSeq GRCh38/hg38
XM_024454102.2 chr4:g.105272894G>A c.4513G>A p.A1505T RefSeq GRCh38/hg38
XM_005263082.3 chr4:g.105272894G>A c.4513G>A p.A1505T RefSeq GRCh38/hg38
XM_006714242 chr4:g.105275323G>A c.4513G>A p.A1505T RefSeq GRCh38/hg38
NM_001127208.2 chr4:g.105272894G>A c.4513G>A p.A1505T RefSeq GRCh38/hg38
XM_006714242.4 chr4:g.105275323G>A c.4513G>A p.A1505T RefSeq GRCh38/hg38
XM_006714242.3 chr4:g.105275323G>A c.4513G>A p.A1505T RefSeq GRCh38/hg38
NM_001127208.3 chr4:g.105272894G>A c.4513G>A p.A1505T RefSeq GRCh38/hg38
XM_024454103.1 chr4:g.105272894G>A c.4513G>A p.A1505T RefSeq GRCh38/hg38
XM_024454102.1 chr4:g.105272894G>A c.4513G>A p.A1505T RefSeq GRCh38/hg38
XM_024454103.2 chr4:g.105272894G>A c.4513G>A p.A1505T RefSeq GRCh38/hg38
XM_005263082.4 chr4:g.105272894G>A c.4513G>A p.A1505T RefSeq GRCh38/hg38

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Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References