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|Variant||ETV6 - FGFR1|
|Protein Effect||gain of function - predicted|
|Gene Variant Descriptions||ETV6-FGFR1 results from the fusion of ETV6 (also referred to as TEL) and FGFR1 (PMID: 21764904), and demonstrates transforming ability in cell culture (PMID: 20338520) and therefore, is predicted to confer a gain of function.|
|Associated Drug Resistance|
|Molecular Profile||Protein Effect||Treatment Approaches|
|ETV6 - FGFR1||gain of function - predicted|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|ETV6 - FGFR1||Advanced Solid Tumor||sensitive||AZD4547||Preclinical - Cell culture||Actionable||In a preclinical study, treatment with AZD4547 decreased Myc expression and inhibited growth of transformed cells expressing ETV6-FGFR1 (TEL-FGFR1) in culture (PMID: 27401245).||27401245|