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|Variant||ETV6 - FGFR4|
|Protein Effect||gain of function|
|Gene Variant Descriptions||ETV6-FGFR4 results from the fusion of ETV6 (also referred to as TEL) and FGFR4 (PMID: 24124571), and demonstrates constitutive kinase activity and the ability to transform cells in culture (PMID: 24124571).|
|Associated Drug Resistance|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|ETV6 - FGFR4||Advanced Solid Tumor||sensitive||AZD4547||Preclinical - Cell culture||Actionable||In a preclinical study, treatment with AZD4547 decreased Myc expression and inhibited growth of transformed cells expressing ETV6-FGFR4 (TEL-FGFR4) in culture (PMID: 27401245).||27401245|
|Molecular Profile||Protein Effect||Treatment Approaches|
|ETV6 - FGFR4||gain of function|