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Gene FGFR2
Variant V564M
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR2 V564M lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). V564M has been demonstrated to confer resistance to Fgfr inhibitors in culture (PMID: 25349422), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2023).
Associated Drug Resistance Y
Category Variants Paths

FGFR2 mutant FGFR2 V564M

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Transcript NM_000141.5
gDNA chr10:g.121496703_121496705delGTTinsATG
cDNA c.1690_1692delGTTinsATG
Protein p.V564M
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001144916.2 chr10:g.121487374_121487376delGTAinsATG c.1690_1692delGTAinsATG p.V564M RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121496703_121496705delGTTinsATG c.1690_1692delGTTinsATG p.V564M RefSeq GRCh38/hg38
NM_001144916 chr10:g.121487374_121487376delTACinsCAT c.1690_1692delGTAinsATG p.V564M RefSeq GRCh38/hg38
NM_000141 chr10:g.121496703_121496705delAACinsCAT c.1690_1692delGTTinsATG p.V564M RefSeq GRCh38/hg38
NM_001144916.1 chr10:g.121487374_121487376delGTAinsATG c.1690_1692delGTAinsATG p.V564M RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121496703_121496705delGTTinsATG c.1690_1692delGTTinsATG p.V564M RefSeq GRCh38/hg38
XM_024447887.2 chr10:g.121488075_121488077delGTAinsATG c.1690_1692delGTAinsATG p.V564M RefSeq GRCh38/hg38
XM_024447887.1 chr10:g.121488075_121488077delGTAinsATG c.1690_1692delGTAinsATG p.V564M RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR2 V564M Advanced Solid Tumor resistant Infigratinib Preclinical - Cell culture Actionable In a preclinical study, transformed cells expressing FGFR2 V564M were resistant to Truseltiq (infigratinib) in culture (PMID: 25349422). 25349422