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Gene RET
Variant I788N
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RET I788N lies within the protein kinase domain of the Ret protein (UniProt.org). I788N has been associated with drug resistance in the context of RET fusions (PMID: 28615362), but has not been biochemically characterized and therefore, its effect on Ret protein function is unknown (PubMed, Jan 2024).
Associated Drug Resistance Y
Category Variants Paths

RET mutant RET I788N

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Transcript NM_020975.6
gDNA chr10:g.43118451T>A
cDNA c.2363T>A
Protein p.I788N
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001406759.1 chr10:g.43118451T>A c.2363T>A p.I788N RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43118451T>A c.2363T>A p.I788N RefSeq GRCh38/hg38
NM_020975 chr10:g.43118451T>A c.2363T>A p.I788N RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43118451T>A c.2363T>A p.I788N RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43118451T>A c.2363T>A p.I788N RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43118451T>A c.2363T>A p.I788N RefSeq GRCh38/hg38
NM_020630 chr10:g.43118451T>A c.2363T>A p.I788N RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43118451T>A c.2363T>A p.I788N RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43118451T>A c.2363T>A p.I788N RefSeq GRCh38/hg38
NM_001406769.1 chr10:g.43121974T>A c.2363T>A p.I788N RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43118451T>A c.2363T>A p.I788N RefSeq GRCh38/hg38
NM_001406772.1 chr10:g.43121974T>A c.2363T>A p.I788N RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References