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|Protein Effect||loss of function|
|Gene Variant Descriptions||FANCA inact mut indicates that this variant results in a loss of function of the Fanca protein. However, the specific amino acid change has not been identified.|
|Associated Drug Resistance|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|FANCA inact mut||prostate cancer||predicted - sensitive||Olaparib||Case Reports/Case Series||Actionable||In a Phase II (TOPARP-B) trial, Lynparza (olaparib) treatment resulted in a composite overall response rate of 20.0% (4/20) and a RECIST objective response rate of 0% (0/17) in patients with castration-resistant prostate cancer harboring deleterious mutations in DNA damage response genes, including ARID1A, ATRX, CHEK1/2, FANCA, FANCF, FANCG, FANCI, FANCM, MSH2, NBN, RAD50, and WRN (n=1, 1, 1, 5, 5, 2, 1, 1, 2, 1, 1, 1, 7, respectively) (PMID: 31806540; NCT01682772).||31806540|
|FANCA inact mut||prostate cancer||predicted - sensitive||Rucaparib||Case Reports/Case Series||Actionable||In a Phase II trial, 1 of 4 patients with deleterious FANCA alterations demonstrated a PSA response and complete radiographic response, which were ongoing at the time of visit cutoff (PMID: 32086346; NCT02952534).||32086346|
|Molecular Profile||Protein Effect||Treatment Approaches|
|FANCA inact mut||loss of function|