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Gene MDM2
Variant V234L
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions MDM2 V234L (corresponding to V228L in the canonical isoform) lies within the ARF-binding region of the Mdm2 protein (UniProt.org). V234L demonstrates ability to degrade Tp53 similar to wild-type Mdm2 in culture (PMID: 27308622), and therefore, is predicted to have no effect on Mdm2 protein function.
Associated Drug Resistance
Category Variants Paths

MDM2 mutant MDM2 V234L

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Transcript NM_002392.6
gDNA chr12:g.68835844G>C
cDNA c.700G>C
Protein p.V234L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002392.6 chr12:g.68835844G>C c.700G>C p.V234L RefSeq GRCh38/hg38
NM_002392 chr12:g.68835844G>C c.700G>C p.V234L RefSeq GRCh38/hg38
NM_002392.5 chr12:g.68835844G>C c.700G>C p.V234L RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References