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Gene PIK3CA
Variant K944N
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions PIK3CA K944N lies within the PI3K/PI4K domain of the Pik3ca protein (UniProt.org). K944N results in activation of Pik3ca signaling as indicated by increased phosphorylation of Akt and Mapk3/Mapk1 (Erk1/2), and confers resistance to some EGFR inhibitors in cell culture (PMID: 28424201) and therefore, is predicted to lead to a gain of Pik3ca protein function.
Associated Drug Resistance Y
Category Variants Paths

PIK3CA mutant PIK3CA act mut PIK3CA K944N

PIK3CA mutant PIK3CA exon20 PIK3CA K944N

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Transcript NM_006218.4
gDNA chr3:g.179230272A>C
cDNA c.2832A>C
Protein p.K944N
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_006218 chr3:g.179230272A>C c.2832A>C p.K944N RefSeq GRCh38/hg38
XM_011512894 chr3:g.179230272A>C c.2832A>C p.K944N RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179230272A>C c.2832A>C p.K944N RefSeq GRCh38/hg38
XM_006713658 chr3:g.179230272A>C c.2832A>C p.K944N RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179230272A>C c.2832A>C p.K944N RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179230272A>C c.2832A>C p.K944N RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179230272A>C c.2832A>C p.K944N RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179230272A>C c.2832A>C p.K944N RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PIK3CA K944N colorectal cancer resistant Cetuximab + Fluorouracil Case Reports/Case Series Actionable In a clinical study, PIK3CA K944N was identified as a potential mechanism for acquired Erbitux (cetuximab) resistance in two colorectal cancer patients, which is supported by cell culture studies demonstrating resistance to Erbitux (cetuximab) and Fluorouracil combination treatment in colorectal cancer cells over expressing PIK3CA K944N (PMID: 28424201). 28424201