Gene Variant Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Gene TP53
Variant S215G
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions TP53 S215G lies within the DNA-binding domain of the Tp53 protein (PMID: 15510160). S215G results in decreased Tp53 transactivation activity and leads to reduced apoptosis relative to wild type Tp53 in cell culture (PMID: 22862161).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon6 TP53 S215G

TP53 mutant TP53 inact mut TP53 S215G

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Transcript NM_000546.5
gDNA chr17:g.7674888T>C
cDNA c.643A>G
Protein p.S215G
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001126114.2 chr17:g.7674888T>C c.643A>G p.S215G RefSeq GRCh38/hg38
NM_000546 chr17:g.7674888T>C c.643A>G p.S215G RefSeq GRCh38/hg38
NM_001126113 chr17:g.7674888T>C c.643A>G p.S215G RefSeq GRCh38/hg38
NM_001126114 chr17:g.7674888T>C c.643A>G p.S215G RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7674888T>C c.643A>G p.S215G RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7674888T>C c.643A>G p.S215G RefSeq GRCh38/hg38
NM_001126112 chr17:g.7674888T>C c.643A>G p.S215G RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7674888T>C c.643A>G p.S215G RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
TP53 S215G lung non-small cell carcinoma resistant Seliciclib Preclinical - Cell culture Actionable In a preclinical study, non-small cell lung carcinoma cells overexpressing TP53 S215G were resistant to Roscovotine (seliciclib) induced apoptosis in culture (PMID: 22862161). 22862161