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Gene DNMT3A
Variant R478Q
Impact List missense
Protein Effect unknown
Gene Variant Descriptions DNMT3A R478Q does not lie within any known functional domains of the Dnmt3a protein (UniProt.org). R478Q has not been characterized in the scientific literature and therefore, its effect on Dnmt3a protein function is unknown (PubMed, Jan 2024).
Associated Drug Resistance
Category Variants Paths

DNMT3A mutant DNMT3A R478Q

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Transcript NM_022552.5
gDNA chr2:g.25246061C>T
cDNA c.1433G>A
Protein p.R478Q
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_022552.4 chr2:g.25246061C>T c.1433G>A p.R478Q RefSeq GRCh38/hg38
NM_175629 chr2:g.25246061C>T c.1433G>A p.R478Q RefSeq GRCh38/hg38
XM_005264175.5 chr2:g.25246061C>T c.1433G>A p.R478Q RefSeq GRCh38/hg38
XM_047443593.1 chr2:g.25246061C>T c.1433G>A p.R478Q RefSeq GRCh38/hg38
XM_005264175.6 chr2:g.25246061C>T c.1433G>A p.R478Q RefSeq GRCh38/hg38
NM_022552.5 chr2:g.25246061C>T c.1433G>A p.R478Q RefSeq GRCh38/hg38
XM_017003526 chr2:g.25246061C>T c.1433G>A p.R478Q RefSeq GRCh38/hg38
NM_175629.2 chr2:g.25246061C>T c.1433G>A p.R478Q RefSeq GRCh38/hg38
NM_022552 chr2:g.25246061C>T c.1433G>A p.R478Q RefSeq GRCh38/hg38
XM_005264175 chr2:g.25246061C>T c.1433G>A p.R478Q RefSeq GRCh38/hg38
XM_017003526.1 chr2:g.25246061C>T c.1433G>A p.R478Q RefSeq GRCh38/hg38
XM_017003526.2 chr2:g.25246061C>T c.1433G>A p.R478Q RefSeq GRCh38/hg38
XM_011532664.2 chr2:g.25246061C>T c.1433G>A p.R478Q RefSeq GRCh38/hg38
XM_011532664.3 chr2:g.25246061C>T c.1433G>A p.R478Q RefSeq GRCh38/hg38
XM_011532664 chr2:g.25246061C>T c.1433G>A p.R478Q RefSeq GRCh38/hg38
NM_175629.2 chr2:g.25246061C>T c.1433G>A p.R478Q RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References