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Gene CDK12
Variant T212fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions CDK12 T212fs results in a change in the amino acid sequence of the Cdk12 protein beginning at aa 212 of 1490, likely resulting in premature truncation of the functional protein (UniProt.org). T212fs has not been biochemically characterized, however, due to the effects of other truncation mutations downstream of T212 (PMID: 24554720, PMID: 25712099), is predicted to lead to a loss of Cdk12 protein function.
Associated Drug Resistance
Category Variants Paths

CDK12 mutant CDK12 inact mut CDK12 T212fs

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Transcript NM_016507.4
gDNA chr17:g.(39462704_39462705)
cDNA c.(634_633)
Protein p.T212fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011524895.2 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_017024748.1 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_047436265.1 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_011524907.3 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_047436257.1 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_011524902 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_011524898.3 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_005257456.4 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_017024749 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_011524898 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_011524893.2 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_047436267.1 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_047436258.1 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_047436290.1 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_011524895 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_011524896 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_017024752.1 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_011524900 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_011524906.3 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_011524906.2 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_011524892.2 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_011524897 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_017024745 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_047436288.1 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_047436282.1 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_011524892 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_047436256.1 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_011524898.2 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
NM_015083.4 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_011524907.2 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_047436289.1 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_047436276.1 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
NM_015083 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_047436291.1 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_047436277.1 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_017024746 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_017024750.1 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_047436278.1 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_011524897.2 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
NM_016507.3 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_011524895.3 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_047436275.1 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_005257458.4 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_047436292.1 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_011524893 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_005257456 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_047436285.1 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_011524903.2 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_047436268.1 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_017024753.2 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_047436264.1 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_047436280.1 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_047436269.1 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_047436253.1 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
NM_016507 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_047436293.1 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_011524903 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_011524907 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_017024753 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_047436287.1 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_047436263.1 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_017024747.1 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_011524905.2 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_047436286.1 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_011524902.2 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_017024751 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_011524901.2 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_047436261.1 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_047436279.1 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_047436255.1 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_017024752 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_011524894.3 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_011524901 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_047436273.1 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_011524899.2 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_047436281.1 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_017024744 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_017024750 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_011524894.2 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_011524906 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_011524900.2 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_017024749.1 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_047436266.1 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
NM_016507.4 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_024450801.1 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_011524905 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_005257456.5 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_011524899 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_047436259.1 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_011524893.3 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_047436272.1 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_047436262.1 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_005257458 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_047436283.1 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_047436274.1 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_011524897.3 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_011524894 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_047436284.1 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_011524896.2 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
NM_015083.2 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_047436270.1 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_047436260.1 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_017024753.3 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_017024747 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_017024748 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38
XM_017024751.1 chr17:g.(39462704_39462705) c.(634_633) p.T212fs RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References