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Gene | HRAS |
Variant | T58I |
Impact List | missense |
Protein Effect | loss of function |
Gene Variant Descriptions | HRAS T58I does not lie within any known functional domains of the Hras protein (UniProt.org). T58I confers a loss of function on the Hras protein as indicated by decreased GTP hydrolysis and binding to GEF proteins, leading to constitutive activation of Hras signaling in culture (PMID: 26888048). |
Associated Drug Resistance |
Transcript | NM_005343.3 |
gDNA | chr11:g.533883G>A |
cDNA | c.173C>T |
Protein | p.T58I |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_176795.4 | chr11:g.533883G>A | c.173C>T | p.T58I | RefSeq | GRCh38/hg38 |
NM_176795 | chr11:g.533883G>A | c.173C>T | p.T58I | RefSeq | GRCh38/hg38 |
NM_005343.3 | chr11:g.533883G>A | c.173C>T | p.T58I | RefSeq | GRCh38/hg38 |
NM_001130442 | chr11:g.533883G>A | c.173C>T | p.T58I | RefSeq | GRCh38/hg38 |
NM_001130442.2 | chr11:g.533883G>A | c.173C>T | p.T58I | RefSeq | GRCh38/hg38 |
NM_005343 | chr11:g.533883G>A | c.173C>T | p.T58I | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|
Molecular Profile | Protein Effect | Treatment Approaches |
---|---|---|
HRAS T58I | loss of function | MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan) |