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Gene ETV6 JAK3
Variant ETV6 - JAK3
Impact List fusion
Protein Effect gain of function
Gene Variant Descriptions ETV6-JAK3 results from the fusion of ETV6 and JAK3, which leads to constitutive activation of Stat1 and Stat3, increased expression of Stat5 target genes, and is transforming in cell culture (PMID: 10706877).
Associated Drug Resistance

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No Variant Reference Transcript is Available.
No transcript is Available.

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
ETV6 - JAK3 gain of function
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ETV6 - JAK3 hematologic cancer sensitive Pyridone 6 Preclinical - Cell culture Actionable In a preclinical study, Pyridone 6 (CMP6) inhibited proliferation of transformed mouse Ba/F3 cells expressing ETV6-JAK3 in culture (PMID: 23471820). 23471820
ETV6 - JAK3 hematologic cancer predicted - resistant NS-018 Preclinical - Cell culture Actionable In a preclinical study, cells expressing ETV6-JAK3 were insensitive to treatment with NS-108 in culture (PMID: 22829185). 22829185