Gene Variant Detail

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Gene ERBB2
Variant L755_E757delinsS
Impact List insertion
Protein Effect unknown
Gene Variant Descriptions ERBB2 (HER2) L755_E757delinsS results in the deletion of three amino acids from aa 755 to 757 within the protein kinase domain of the Erbb2 (Her2) protein, combined with the insertion of a serine (S) at the same site (UniProt.org). L755_E757delinsS has been identified in the scientific literature (PMID: 29420467), but has not been biochemically characterized and therefore, its effect on Erbb2 (Her2) protein function is unknown (PubMed, Oct 2019).
Associated Drug Resistance

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Transcript NM_004448
gDNA chr17:g.39723966_39723974delinsAGC
cDNA c.2263_2271delinsAGC
Protein p.L755_E757delinsS
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001289937 chr17:g.39723966_39723974delinsAGC c.2263_2271delinsAGC p.L755_E757delinsS RefSeq GRCh38/hg38
NM_004448 chr17:g.39723966_39723974delinsAGC c.2263_2271delinsAGC p.L755_E757delinsS RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
ERBB2 L755_E757delinsS unknown
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ERBB2 L755_E757delinsS Her2-receptor negative breast cancer predicted - sensitive Neratinib Phase II Actionable In a Phase II trial (SUMMIT), Nerlynx (neratinib) treatment resulted in partial response with a progression-free survival of 9.0 months in a patient with Erbb2 (Her2) receptor negative (non-amplified) breast cancer harboring ERBB2 (HER2) L755_E757delinsS (PMID: 29420467; NCT01953926). 29420467