Gene Variant Detail

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Gene ERBB2
Variant P761del
Impact List deletion
Protein Effect unknown
Gene Variant Descriptions ERBB2 (HER2) P761del results in the deletion of one amino acid in the protein kinase domain of the Erbb2 (Her2) protein at amino acid 761 (UniProt.org). P761del has been identified in the scientific literature (PMID: 29420467), but has not been biochemically characterized and therefore, its effect on Erbb2 (Her2) protein function is unknown (PubMed, Oct 2019).
Associated Drug Resistance

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Transcript NM_004448
gDNA chr17:g.39723984_39723986delCCC
cDNA c.2281_2283delCCC
Protein p.P761delP
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004448 chr17:g.39723984_39723986delCCC c.2281_2283delCCC p.P761delP RefSeq GRCh38/hg38
NM_001289936 chr17:g.39724745_39724747delGTG c.2282_2284delGTG p.G761delG RefSeq GRCh38/hg38
NM_001289937 chr17:g.39723984_39723986delCCC c.2281_2283delCCC p.P761delP RefSeq GRCh38/hg38
NM_001005862 chr17:g.39724789_39724791delACA c.2281_2283delACA p.T761delT RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Molecular Profile Protein Effect Treatment Approaches
ERBB2 P761del unknown
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ERBB2 P761del endometrial cancer predicted - resistant Neratinib Phase II Actionable In a Phase II trial (SUMMIT), Nerlynx (neratinib) treatment resulted in progressive disease with a progression-free survival of 1.9 months in a patient with endometrial cancer harboring ERBB2 (HER2) P761del (PMID: 29420467; NCT01953926). 29420467