Gene Variant Detail

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Gene ROS1
Variant D2113N
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ROS1 D2113N lies within the protein kinase domain of the Ros1 protein (UniProt.org). D2113N has been demonstrated to enhance resistance to Ros1 tyrosine kinase inhibitors with a concurrent ROS1 G2032R in the context of Ros1 fusion in culture (PMID: 26372962), but has not been biochemically characterized and therefore, its effect on Ros1 protein function is unknown (PubMed, Mar 2022).
Associated Drug Resistance Y

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Transcript NM_002944.2
gDNA chr6:g.117310178C>T
cDNA c.6337G>A
Protein p.D2113N
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002944.2 chr6:g.117310178C>T c.6337G>A p.D2113N RefSeq GRCh38/hg38
NM_002944 chr6:g.117310178C>T c.6337G>A p.D2113N RefSeq GRCh38/hg38

Filtering

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  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Molecular Profile Protein Effect Treatment Approaches
ROS1 D2113N unknown