Gene Variant Detail

Gene AKT1
Variant R121W
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions AKT1 R121W does not lie within any known functional domains of the Akt1 protein (UniProt.org). R121W results in similar cell proliferation and viability levels as wild-type Akt1 (PMID: 29533785, PMID: 26701849) and therefore, is predicted to have no effect on the Akt1 protein.
Associated Drug Resistance

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Transcript NM_001014432
gDNA chr14:g.104775726G>A
cDNA c.361C>T
Protein p.R121W
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001014432 chr14:g.104775726G>A c.361C>T p.R121W RefSeq GRCh38/hg38
XM_017021077 chr14:g.104775726G>A c.361C>T p.R121W RefSeq GRCh38/hg38
NM_001014431 chr14:g.104775726G>A c.361C>T p.R121W RefSeq GRCh38/hg38
NM_005163 chr14:g.104775726G>A c.361C>T p.R121W RefSeq GRCh38/hg38
XM_005267401 chr14:g.104775726G>A c.361C>T p.R121W RefSeq GRCh38/hg38
XM_017021076 chr14:g.104775726G>A c.361C>T p.R121W RefSeq GRCh38/hg38
XM_017021078 chr14:g.104775726G>A c.361C>T p.R121W RefSeq GRCh38/hg38
XM_017021075 chr14:g.104775726G>A c.361C>T p.R121W RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
AKT1 R121W no effect - predicted
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References