Gene Variant Detail

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Gene BRAF
Variant A320T
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions BRAF A320T does not lie within any known functional domains of the Braf protein (UniProt.org). A320T has not been biochemically characterized, but results in similar cell proliferation and viability levels to wild-type Braf in culture (PMID: 29533785), and therefore is predicted to have no effect on Braf protein function.
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF A320T

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Transcript NM_004333.5
gDNA chr7:g.140800384C>T
cDNA c.958G>A
Protein p.A320T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_017012559 chr7:g.140800384C>T c.958G>A p.A320T RefSeq GRCh38/hg38
XM_017012558.1 chr7:g.140800384C>T c.958G>A p.A320T RefSeq GRCh38/hg38
XM_017012558 chr7:g.140800384C>T c.958G>A p.A320T RefSeq GRCh38/hg38
XM_005250045 chr7:g.140800384C>T c.958G>A p.A320T RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140800384C>T c.958G>A p.A320T RefSeq GRCh38/hg38
XM_017012559.1 chr7:g.140800384C>T c.958G>A p.A320T RefSeq GRCh38/hg38
NM_004333 chr7:g.140800384C>T c.958G>A p.A320T RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140800384C>T c.958G>A p.A320T RefSeq GRCh38/hg38

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  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References