Gene Variant Detail

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Gene BRAF
Variant K205Q
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions BRAF K205Q lies within the RBD domain of the Braf protein (UniProt.org). K205Q has not been biochemically characterized, but results in similar cell proliferation and viability levels as wild-type Braf in culture (PMID: 29533785), and therefore, is predicted to have no effect on Braf protein function.
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF K205Q

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Transcript NM_004333.6
gDNA chr7:g.140808058T>G
cDNA c.613A>C
Protein p.K205Q
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001378475.1 chr7:g.140800465T>G c.613A>C p.K205Q RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140808058T>G c.613A>C p.K205Q RefSeq GRCh38/hg38
XM_005250045 chr7:g.140808058T>G c.613A>C p.K205Q RefSeq GRCh38/hg38
XM_047420767.1 chr7:g.140808058T>G c.613A>C p.K205Q RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140808058T>G c.613A>C p.K205Q RefSeq GRCh38/hg38
XM_017012558.1 chr7:g.140808058T>G c.613A>C p.K205Q RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140808058T>G c.613A>C p.K205Q RefSeq GRCh38/hg38
XM_017012559.2 chr7:g.140808058T>G c.613A>C p.K205Q RefSeq GRCh38/hg38
XM_047420768.1 chr7:g.140808058T>G c.613A>C p.K205Q RefSeq GRCh38/hg38
NM_001378469.1 chr7:g.140808058T>G c.613A>C p.K205Q RefSeq GRCh38/hg38
NM_004333 chr7:g.140808058T>G c.613A>C p.K205Q RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140808058T>G c.613A>C p.K205Q RefSeq GRCh38/hg38
NM_001374258.1 chr7:g.140808058T>G c.613A>C p.K205Q RefSeq GRCh38/hg38
XM_017012558 chr7:g.140808058T>G c.613A>C p.K205Q RefSeq GRCh38/hg38
XM_047420769.1 chr7:g.140808058T>G c.613A>C p.K205Q RefSeq GRCh38/hg38
XM_017012559 chr7:g.140808058T>G c.613A>C p.K205Q RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140808058T>G c.613A>C p.K205Q RefSeq GRCh38/hg38
XM_017012559.1 chr7:g.140808058T>G c.613A>C p.K205Q RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140808058T>G c.613A>C p.K205Q RefSeq GRCh38/hg38
NM_001378471.1 chr7:g.140808058T>G c.613A>C p.K205Q RefSeq GRCh38/hg38
NM_001374244.1 chr7:g.140808058T>G c.613A>C p.K205Q RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References