Gene Variant Detail

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Gene BRAF
Variant V504I
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions BRAF V504I lies within the protein kinase domain of the Braf protein (UniProt.org). V504I has not been biochemically characterized, but results in similar cell proliferation and viability levels as wild-type Braf (PMID: 29533785).
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF V504I

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Transcript NM_004333.5
gDNA chr7:g.140777998C>T
cDNA c.1510G>A
Protein p.V504I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_005250045 chr7:g.140777998C>T c.1510G>A p.V504I RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140777998C>T c.1510G>A p.V504I RefSeq GRCh38/hg38
NM_004333 chr7:g.140777998C>T c.1510G>A p.V504I RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140777998C>T c.1510G>A p.V504I RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
BRAF V504I no effect - predicted