Gene Variant Detail

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Gene RET
Variant D631_R635delinsG
Impact List indel
Protein Effect unknown
Gene Variant Descriptions RET D631_R635delinsG results in a deletion of five amino acids in the extracellular domain of the Ret protein from amino acids 631 to 635, combined with the insertion of one glycine (G) at the same site (UniProt.org). D631_R635delinsG has been identified in the scientific literature (PMID: 29657135), but has not been biochemically characterized and therefore, its effect on Ret protein function is unknown (PubMed, Jan 2020).
Associated Drug Resistance

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Transcript NM_020975
gDNA chr10:g.43114492_43114503del12
cDNA c.1892_1903del12
Protein p.D631_R635delinsG
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020975 chr10:g.43114492_43114503del12 c.1892_1903del12 p.D631_R635delinsG RefSeq GRCh38/hg38
NM_020630 chr10:g.43114492_43114503del12 c.1892_1903del12 p.D631_R635delinsG RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
RET D631_R635delinsG unknown
RET L629P RET D631_R635delinsG RET V637R
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RET L629P RET D631_R635delinsG RET V637R thyroid gland medullary carcinoma predicted - sensitive BLU-667 Phase I Actionable In a Phase I trial, a patient with medullary thryoid cancer harboring RET D631_R635delinsG, L629P, and V637R demonstrated a partial response, with maximal tumor reduction of 47% at 10 months, following treatment with BLU-667 (PMID: 29657135; NCT03037385). 29657135