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Gene RET
Variant D631_R635delinsG
Impact List indel
Protein Effect unknown
Gene Variant Descriptions RET D631_R635delinsG results in a deletion of five amino acids in the extracellular domain of the Ret protein from amino acids 631 to 635, combined with the insertion of one glycine (G) at the same site (UniProt.org). D631_R635delinsG has been identified in the scientific literature (PMID: 29657135), but has not been biochemically characterized and therefore, its effect on Ret protein function is unknown (PubMed, Dec 2023).
Associated Drug Resistance
Category Variants Paths

RET mutant RET D631_R635delinsG

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Transcript NM_020975.6
gDNA chr10:g.43114492_43114503del12
cDNA c.1892_1903del12
Protein p.D631_R635delinsG
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020975 chr10:g.43114492_43114503del12 c.1892_1903del12 p.D631_R635delinsG RefSeq GRCh38/hg38
NM_020630 chr10:g.43114492_43114503del12 c.1892_1903del12 p.D631_R635delinsG RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43114492_43114503del12 c.1892_1903del12 p.D631_R635delinsG RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43114492_43114503del12 c.1892_1903del12 p.D631_R635delinsG RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43114492_43114503del12 c.1892_1903del12 p.D631_R635delinsG RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43114492_43114503del12 c.1892_1903del12 p.D631_R635delinsG RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43114492_43114503del12 c.1892_1903del12 p.D631_R635delinsG RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43114492_43114503del12 c.1892_1903del12 p.D631_R635delinsG RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43114492_43114503del12 c.1892_1903del12 p.D631_R635delinsG RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43114492_43114503del12 c.1892_1903del12 p.D631_R635delinsG RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References