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|Variant||FGFR2 - DNM3|
|Protein Effect||gain of function|
|Gene Variant Descriptions||FGFR2-DNM3 results from the fusion of FGFR2 and DNM3, resulting in FGFR2 activation, increased PI3K and MAPK pathway signaling, and increased colony formation in culture (PMID: 29203461). FGFR2-DNM3 has been identified in triple-receptor negative breast cancer (PMID: 29203461).|
|Associated Drug Resistance|