Gene Variant Detail

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Gene PIK3CA
Variant E110del
Impact List deletion
Protein Effect gain of function - predicted
Gene Variant Descriptions PIK3CA E110del results in the deletion of an amino acid in an unknown region of the Pik3ca protein (UniProt.org). E110del has not been biochemically characterized, but is predicted to confer a gain of function on the Pik3ca protein as demonstrated by increased transformation ability in two different cell lines (PMID: 29533785).
Associated Drug Resistance

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Transcript NM_006218
gDNA chr3:g.179199153_179199155delGAA
cDNA c.328_330delGAA
Protein p.E110delE
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_006218 chr3:g.179199153_179199155delGAA c.328_330delGAA p.E110delE RefSeq GRCh38/hg38
XM_011512894 chr3:g.179199153_179199155delGAA c.328_330delGAA p.E110delE RefSeq GRCh38/hg38
XM_006713658 chr3:g.179199153_179199155delGAA c.328_330delGAA p.E110delE RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References