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|Gene Variant Descriptions||ERBB2 (HER2) A440T lies within the extracellular domain of the Erbb2 (Her2) protein (UniProt.org). A440T induces increased cell proliferation and cell viability as compared to wild-type Erbb2 (Her2) in one of two different cell lines in culture (PMID: 29533785), but has not been biochemically characterized and therefore, its effect on Erbb2 (Her2) protein function is unknown (PubMed, Apr 2020).|
|Associated Drug Resistance|
|Transcript||gDNA||cDNA||Protein||Source Database||Genome Build|