Gene Variant Detail

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Gene ERBB2
Variant A775_G776insIRDG
Impact List insertion
Protein Effect no effect - predicted
Gene Variant Descriptions ERBB2 (HER2) A775_G776insIRDG results in the insertion of four amino acids in the protein kinase domain of the Erbb2 (Her2) protein between amino acids 775 and 776 (UniProt.org). A775_G776insIRDG has not been biochemically characterized, but results in similar cell proliferation and viability levels as wild-type Erbb2 (Her2) (PMID: 29533785) and therefore, is predicted to have no effect on Erbb2 (Her2) protein function.
Associated Drug Resistance

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Transcript NM_004448
gDNA chr17:g.39724743_39724744insATCAGGGACGGT
cDNA c.2325_2326insATCAGGGACGGT
Protein p.A775_G776insIRDG
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004448 chr17:g.39724743_39724744insATCAGGGACGGT c.2325_2326insATCAGGGACGGT p.A775_G776insIRDG RefSeq GRCh38/hg38
NM_001289937 chr17:g.39724743_39724744insATCAGGGACGGT c.2325_2326insATCAGGGACGGT p.A775_G776insIRDG RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

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  • Click on any column header arrows to sort by that column
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Molecular Profile Protein Effect Treatment Approaches
ERBB2 A775_G776insIRDG no effect - predicted
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References