Gene Variant Detail

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Gene PIK3CA
Variant H1047T
Impact List missense
Protein Effect unknown
Gene Variant Descriptions PIK3CA H1047T is a hotspot mutation that lies within the PI3K/PI4K domain of the Pik3ca protein (UniProt.org). H1047T has identified in the scientific literature (PMID: 29636477), but has not been biochemically characterized and therefore, its effect on Pik3ca protein function is unknown (PubMed, Oct 2019).
Associated Drug Resistance

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Transcript NM_006218
gDNA chr3:g.179234296_179234297delCAinsAC
cDNA c.3139_3140delCAinsAC
Protein p.H1047T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011512894 chr3:g.179234296_179234297delCAinsAC c.3139_3140delCAinsAC p.H1047T RefSeq GRCh38/hg38
XM_006713658 chr3:g.179234296_179234297delCAinsAC c.3139_3140delCAinsAC p.H1047T RefSeq GRCh38/hg38
NM_006218 chr3:g.179234296_179234297delCAinsAC c.3139_3140delCAinsAC p.H1047T RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Molecular Profile Protein Effect Treatment Approaches
PIK3CA H1047T unknown
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References