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Gene DNMT3A
Variant R836W
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions DNMT3A R836W lies within the SAM-dependent MTase C5-type domain of the Dnmt3a protein (UniProt.org). R836W results in modestly reduced Dnmt3A activity and overall methylation, with increased non-CpG methylation, and cytokine-independent growth in cell culture (PMID: 29414941), and therefore, is predicted to lead to a loss of Dnmt3a protein function.
Associated Drug Resistance
Category Variants Paths

DNMT3A mutant DNMT3A inact mut DNMT3A R836W

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Transcript NM_022552.5
gDNA chr2:g.25235798T>A
cDNA c.2506A>T
Protein p.R836W
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011532663 chr2:g.25234347G>A c.2506C>T p.R836W RefSeq GRCh38/hg38
NM_175629.2 chr2:g.25235798T>A c.2506A>T p.R836W RefSeq GRCh38/hg38
XM_011532662.2 chr2:g.25234365T>A c.2506A>T p.R836W RefSeq GRCh38/hg38
XM_011532662.3 chr2:g.25234365T>A c.2506A>T p.R836W RefSeq GRCh38/hg38
NM_022552 chr2:g.25235798T>A c.2506A>T p.R836W RefSeq GRCh38/hg38
XM_011532663.2 chr2:g.25234347G>A c.2506C>T p.R836W RefSeq GRCh38/hg38
XM_017003526.2 chr2:g.25235798T>A c.2506A>T p.R836W RefSeq GRCh38/hg38
NM_175629.2 chr2:g.25235798T>A c.2506A>T p.R836W RefSeq GRCh38/hg38
XM_017003526 chr2:g.25235798T>A c.2506A>T p.R836W RefSeq GRCh38/hg38
XM_005264175.6 chr2:g.25235798T>A c.2506A>T p.R836W RefSeq GRCh38/hg38
NM_022552.5 chr2:g.25235798T>A c.2506A>T p.R836W RefSeq GRCh38/hg38
NM_022552.4 chr2:g.25235798T>A c.2506A>T p.R836W RefSeq GRCh38/hg38
XM_017003526.1 chr2:g.25235798T>A c.2506A>T p.R836W RefSeq GRCh38/hg38
XM_005264175.5 chr2:g.25235798T>A c.2506A>T p.R836W RefSeq GRCh38/hg38
XM_011532662 chr2:g.25234365T>A c.2506A>T p.R836W RefSeq GRCh38/hg38
NM_175629 chr2:g.25235798T>A c.2506A>T p.R836W RefSeq GRCh38/hg38
XM_005264175 chr2:g.25235798T>A c.2506A>T p.R836W RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References