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Gene | FLT3 |
Variant | C695S |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | FLT3 C695S lies within the protein kinase domain of the Flt3 protein (UniProt.org). C695S has been demonstrated to confer resistance to some FLT3 inhibitors (PMID: 29187377), but has not been biochemically characterized and therefore, its effect on Flt3 protein function is unknown (PubMed, Dec 2021). |
Associated Drug Resistance | Y |
Transcript | NM_004119.2 |
gDNA | chr13:g.28027212A>T |
cDNA | c.2083T>A |
Protein | p.C695S |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_004119.2 | chr13:g.28027212A>T | c.2083T>A | p.C695S | RefSeq | GRCh38/hg38 |
NM_004119 | chr13:g.28027212A>T | c.2083T>A | p.C695S | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FLT3 exon 14 ins FLT3 C695S | hematologic cancer | predicted - resistant | FF-10101 | Preclinical - Biochemical | Actionable | In a preclinical study, FF-10101 treatment failed to inhibit Flt3 phosphorylation in transformed human cells expressing FLT3-ITD and FLT3 C695S in culture (PMID: 29187377). | 29187377 |
Molecular Profile | Protein Effect | Treatment Approaches |
---|---|---|
FLT3 C695S | unknown | |
FLT3 exon 14 ins FLT3 C695S |