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Gene MAP2K1
Variant T55P
Impact List missense
Protein Effect unknown
Gene Variant Descriptions MAP2K1 T55P does not lie within any known functional domains of the Map2k1 protein (UniProt.org). T55P results in autophosphorylation levels similar to wild-type Map2k1 in an in vitro assay (PMID: 29753091), but leads to increased Erk phosphorylation in cultured cells in another study (PMID: 32641410), and therefore, its effect on Map2k1 protein function is unknown.
Associated Drug Resistance
Category Variants Paths

MAP2K1 mutant MAP2K1 T55P

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Transcript NM_002755.4
gDNA chr15:g.66435109A>C
cDNA c.163A>C
Protein p.T55P
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002755.4 chr15:g.66435109A>C c.163A>C p.T55P RefSeq GRCh38/hg38
NM_002755.3 chr15:g.66435109A>C c.163A>C p.T55P RefSeq GRCh38/hg38
XM_017022411.3 chr15:g.66435109A>C c.163A>C p.T55P RefSeq GRCh38/hg38
XM_017022411.2 chr15:g.66435109A>C c.163A>C p.T55P RefSeq GRCh38/hg38
XM_017022411 chr15:g.66435109A>C c.163A>C p.T55P RefSeq GRCh38/hg38
NM_002755 chr15:g.66435109A>C c.163A>C p.T55P RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
MAP2K1 T55P Advanced Solid Tumor predicted - sensitive Trametinib Preclinical - Biochemical Actionable In a preclinical study, Mekinist (trametinib) inhibited Erk phosphorylation in transformed cells expressing MAP2K1 T55P in culture (PMID: 32641410). 32641410