Gene Variant Detail

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Gene RET
Variant G810S
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RET G810S lies within the protein kinase domain of the Ret protein (UniProt.org). G810S has been demonstrated to confer resistance to tyrosine kinase inhibitors in the context of RET fusions (PMID: 29908090, PMID: 31988000), but has not been biochemically characterized and therefore, its effect on Ret protein function is unknown (PubMed, Jan 2024).
Associated Drug Resistance Y
Category Variants Paths

RET mutant RET G810S

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Transcript NM_020975.6
gDNA chr10:g.43119566G>A
cDNA c.2428G>A
Protein p.G810S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001406759.1 chr10:g.43119566G>A c.2428G>A p.G810S RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43119566G>A c.2428G>A p.G810S RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43119566G>A c.2428G>A p.G810S RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43119566G>A c.2428G>A p.G810S RefSeq GRCh38/hg38
NM_020975 chr10:g.43119566G>A c.2428G>A p.G810S RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43119566G>A c.2428G>A p.G810S RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43119566G>A c.2428G>A p.G810S RefSeq GRCh38/hg38
NM_020630 chr10:g.43119566G>A c.2428G>A p.G810S RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43119566G>A c.2428G>A p.G810S RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43119566G>A c.2428G>A p.G810S RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RET V804M RET G810S RET L881V RET M918T thyroid gland medullary carcinoma predicted - resistant Selpercatinib Case Reports/Case Series Actionable In a clinical case study, a patient with hereditary medullary thyroid carcinoma harboring germline RET M918T demonstrated disease progression following an initial response to Retevmo (selpercatinib), and ctDNA sequencing revealed a decrease in RET L881V, but an increase in RET V804M and RET G810S (PMID: 31988000). 31988000
RET V804M RET G810S RET M918T Advanced Solid Tumor resistant Selpercatinib Preclinical - Cell culture Actionable In a preclinical study, transformed cells expressing RET V804M, G810S, and M918T were resistant to Retevmo (selpercatinib) treatment in culture (PMID: 33161056). 33161056
RET V804M RET G810S Advanced Solid Tumor predicted - sensitive TY-1091 Preclinical - Biochemical Actionable In a preclinical study, TY-1091 inhibited activity in a cell line expressing RET G810S and V804M in culture (Cancer Res (2023) 83 (7_Supplement): 3419). detail...
RET G810S RET M918T Advanced Solid Tumor predicted - sensitive TY-1091 Preclinical - Biochemical Actionable In a preclinical study, TY-1091 inhibited activity in a cell line expressing RET G810S and M918T in culture (Cancer Res (2023) 83 (7_Supplement): 3419). detail...