Gene Variant Detail

Gene AKT1
Variant S266L
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions AKT1 S266L lies within the protein kinase domain of the Akt1 protein (UniProt.org). S266L has not been biochemically characterized, but is not transforming in cell culture and therefore, is predicted to have no effect on the Akt1 protein (PMID: 26701849), but has been associated with drug resistance in cultured cells (PMID: 30140389).
Associated Drug Resistance Y

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Transcript NM_001014432
gDNA chr14:g.104773486G>A
cDNA c.797C>T
Protein p.S266L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_005163 chr14:g.104773486G>A c.797C>T p.S266L RefSeq GRCh38/hg38
XM_017021077 chr14:g.104773486G>A c.797C>T p.S266L RefSeq GRCh38/hg38
NM_001014432 chr14:g.104773486G>A c.797C>T p.S266L RefSeq GRCh38/hg38
XM_005267401 chr14:g.104773486G>A c.797C>T p.S266L RefSeq GRCh38/hg38
NM_001014431 chr14:g.104773486G>A c.797C>T p.S266L RefSeq GRCh38/hg38
XM_017021076 chr14:g.104773486G>A c.797C>T p.S266L RefSeq GRCh38/hg38
XM_017021075 chr14:g.104773486G>A c.797C>T p.S266L RefSeq GRCh38/hg38
XM_017021078 chr14:g.104773486G>A c.797C>T p.S266L RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Protein Effect Treatment Approaches
AKT1 S266L FGFR1 amp
AKT1 S266L no effect - predicted
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
AKT1 S266L FGFR1 amp lung cancer predicted - resistant PD173074 Preclinical - Cell culture Actionable In a preclinical study, lung cancer cells harboring FGFR1 amplification demonstrated resistance to increasing concentrations of PD173074 in culture and was subsequently, found to have acquired AKT1 S266L (PMID: 30140389). 30140389
AKT1 S266L FGFR1 amp lung cancer predicted - sensitive Uprosertib Preclinical - Cell culture Actionable In a preclinical study, lung cancer cells harboring FGFR1 amplification and AKT1 S266L demonstrated sensitivity to Uprosertib (GSK2141795) in culture, showing decreased phosphorylation of Akt1 targets and reduced cell growth (PMID: 30140389). 30140389