Gene Variant Detail

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Gene BRAF
Variant P367R
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions BRAF P367R does not lie within any known functional domains within the Braf protein (UniProt.org). P367R confers a gain of function to the Braf protein as indicated by increased Erk phosphorylation in culture and tumor formation in animal models, and demonstrates resistance to Egfr inhibitors in culture (PMID: 27478040).
Associated Drug Resistance Y
Category Variants Paths

BRAF mutant BRAF P367X BRAF P367R

BRAF mutant BRAF act mut BRAF P367R

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Transcript NM_004333.6
gDNA chr7:g.140794348G>C
cDNA c.1100C>G
Protein p.P367R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001378468.1 chr7:g.140794348G>C c.1100C>G p.P367R RefSeq GRCh38/hg38
XM_017012559 chr7:g.140794348G>C c.1100C>G p.P367R RefSeq GRCh38/hg38
XM_047420767.1 chr7:g.140794348G>C c.1100C>G p.P367R RefSeq GRCh38/hg38
XM_017012559.2 chr7:g.140794348G>C c.1100C>G p.P367R RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140794348G>C c.1100C>G p.P367R RefSeq GRCh38/hg38
XM_047420769.1 chr7:g.140794348G>C c.1100C>G p.P367R RefSeq GRCh38/hg38
XM_017012558.1 chr7:g.140794348G>C c.1100C>G p.P367R RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140794348G>C c.1100C>G p.P367R RefSeq GRCh38/hg38
XM_047420768.1 chr7:g.140794348G>C c.1100C>G p.P367R RefSeq GRCh38/hg38
NM_001374258.1 chr7:g.140794348G>C c.1100C>G p.P367R RefSeq GRCh38/hg38
NM_001378469.1 chr7:g.140794348G>C c.1100C>G p.P367R RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140794348G>C c.1100C>G p.P367R RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140794348G>C c.1100C>G p.P367R RefSeq GRCh38/hg38
XM_005250045 chr7:g.140794348G>C c.1100C>G p.P367R RefSeq GRCh38/hg38
NM_004333 chr7:g.140794348G>C c.1100C>G p.P367R RefSeq GRCh38/hg38
NM_001378471.1 chr7:g.140794348G>C c.1100C>G p.P367R RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140794348G>C c.1100C>G p.P367R RefSeq GRCh38/hg38
XM_017012558 chr7:g.140794348G>C c.1100C>G p.P367R RefSeq GRCh38/hg38
XM_017012559.1 chr7:g.140794348G>C c.1100C>G p.P367R RefSeq GRCh38/hg38
NM_001374244.1 chr7:g.140794348G>C c.1100C>G p.P367R RefSeq GRCh38/hg38

Filtering

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries