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|Gene Variant Descriptions||FOXL2 H104N lies within the fork-head DNA binding region of the Foxl2 protein (UniProt.org). H104N results in abnormal nuclear and cytoplasmic aggregation in cell culture (PMID: 18372316), however, demonstrates variable levels of promoter activation (PMID: 19515849) as demonstrated by increased SIRT1 and decreased MnSOD activation (PMID: 19010791), and similar Goat FOXL2 promoter activation compared to wild-type protein in reporter assays, and therefore, its effect on Foxl2 protein function is unknown.|
|Associated Drug Resistance|
|Transcript||gDNA||cDNA||Protein||Source Database||Genome Build|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Molecular Profile||Protein Effect||Treatment Approaches|