Gene Variant Detail

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Gene HRAS
Variant A146V
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions HRAS A146V lies within the SAK motif of the Hras protein (PMID: 24224811). A146V does not affect Hras intrinsic GTPase activity, but results in increased nucleotide exchange rates, which leads to increase GTP-bound Hras, activation of downstream signaling, and transformation of cultured cells (PMID: 24224811, PMID: 21850009, PMID: 3043178).
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS act mut HRAS A146V

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Transcript NM_005343.4
gDNA chr11:g.533466G>A
cDNA c.437C>T
Protein p.A146V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001130442.3 chr11:g.533466G>A c.437C>T p.A146V RefSeq GRCh38/hg38
NM_005343.3 chr11:g.533466G>A c.437C>T p.A146V RefSeq GRCh38/hg38
NM_005343.4 chr11:g.533466G>A c.437C>T p.A146V RefSeq GRCh38/hg38
NM_001130442 chr11:g.533466G>A c.437C>T p.A146V RefSeq GRCh38/hg38
NM_176795.5 chr11:g.533466G>A c.437C>T p.A146V RefSeq GRCh38/hg38
NM_001130442.2 chr11:g.533466G>A c.437C>T p.A146V RefSeq GRCh38/hg38
NM_176795.4 chr11:g.533466G>A c.437C>T p.A146V RefSeq GRCh38/hg38
NM_005343 chr11:g.533466G>A c.437C>T p.A146V RefSeq GRCh38/hg38
NM_176795 chr11:g.533466G>A c.437C>T p.A146V RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References