Gene Variant Detail

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Gene HRAS
Variant G12F
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions HRAS G12F does not lie within any known functional domains of the Hras protein (UniProt.org). G12F is transforming in culture (PMID: 6092966), and is predicted to result in a loss of Hras protein function based on the effect of KRAS G12F, which results in decreased Kras GTPase activity and activation of downstream Mapk signaling (PMID: 11668624).
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS act mut HRAS G12F

HRAS mutant HRAS G12X HRAS G12F

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Transcript NM_005343.4
gDNA chr11:g.534288_534289delGGinsTT
cDNA c.34_35delGGinsTT
Protein p.G12F
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001130442.2 chr11:g.534288_534289delGGinsTT c.34_35delGGinsTT p.G12F RefSeq GRCh38/hg38
NM_005343 chr11:g.534288_534289delCCinsAA c.34_35delGGinsTT p.G12F RefSeq GRCh38/hg38
NM_176795.4 chr11:g.534288_534289delGGinsTT c.34_35delGGinsTT p.G12F RefSeq GRCh38/hg38
NM_005343.3 chr11:g.534288_534289delGGinsTT c.34_35delGGinsTT p.G12F RefSeq GRCh38/hg38
NM_176795 chr11:g.534288_534289delCCinsAA c.34_35delGGinsTT p.G12F RefSeq GRCh38/hg38
NM_001130442 chr11:g.534288_534289delCCinsAA c.34_35delGGinsTT p.G12F RefSeq GRCh38/hg38
NM_176795.5 chr11:g.534288_534289delGGinsTT c.34_35delGGinsTT p.G12F RefSeq GRCh38/hg38
NM_005343.4 chr11:g.534288_534289delGGinsTT c.34_35delGGinsTT p.G12F RefSeq GRCh38/hg38
NM_001130442.3 chr11:g.534288_534289delGGinsTT c.34_35delGGinsTT p.G12F RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References