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Gene | HRAS |
Variant | G12F |
Impact List | missense |
Protein Effect | loss of function - predicted |
Gene Variant Descriptions | HRAS G12F does not lie within any known functional domains of the Hras protein (UniProt.org). G12F has not been biochemically characterized, but demonstrates transforming ability in cultured cells (PMID: 6092966) and therefore, is predicted to result in a loss of Hras protein function. |
Associated Drug Resistance |
Transcript | NM_005343.3 |
gDNA | chr11:g.534288_534289delGGinsTT |
cDNA | c.34_35delGGinsTT |
Protein | p.G12F |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_005343 | chr11:g.534288_534289delCCinsAA | c.34_35delGGinsTT | p.G12F | RefSeq | GRCh38/hg38 |
NM_001130442.2 | chr11:g.534288_534289delGGinsTT | c.34_35delGGinsTT | p.G12F | RefSeq | GRCh38/hg38 |
NM_176795 | chr11:g.534288_534289delCCinsAA | c.34_35delGGinsTT | p.G12F | RefSeq | GRCh38/hg38 |
NM_176795.4 | chr11:g.534288_534289delGGinsTT | c.34_35delGGinsTT | p.G12F | RefSeq | GRCh38/hg38 |
NM_005343.3 | chr11:g.534288_534289delGGinsTT | c.34_35delGGinsTT | p.G12F | RefSeq | GRCh38/hg38 |
NM_001130442 | chr11:g.534288_534289delCCinsAA | c.34_35delGGinsTT | p.G12F | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|
Molecular Profile | Protein Effect | Treatment Approaches |
---|---|---|
HRAS G12F | loss of function - predicted | MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan) |