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|Variant||BCORL1 - ELF4|
|Protein Effect||loss of function|
|Gene Variant Descriptions||BCORL1-ELF4 results from the fusion of BCORL1 and ELF4 (PMID: 21499249). BCORL1-ELF4 has been identified in hepatocellular carcinoma (PMID: 21499249) and confers a loss of function, as demonstrated by decreased transcriptional repressor activity in luciferase reporter assays (PMID: 21499249, PMID: 26921333) and loss of the ability to inhibit cell growth in culture (PMID: 26921333).|
|Associated Drug Resistance|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Molecular Profile||Protein Effect||Treatment Approaches|
|BCORL1 - ELF4||loss of function|