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Gene | KDR |
Variant | L840F |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | KDR (VEGFR2) L840F lies within the protein kinase domain of the Kdr (Vegfr2) protein (UniProt.org). L840F is associated with resistance to Kdr (Vegfr2) inhibitors (PMID: 29588308), and results in reduced kinase activity in culture, but demonstrates Erk activation and tumor formation in mouse models (PMID: 29588308), and therefore, its effect on Kdr (Vegfr2) protein function is unknown. |
Associated Drug Resistance | Y |
Transcript | NM_002253.3 |
gDNA | chr4:g.55097758G>A |
cDNA | c.2518C>T |
Protein | p.L840F |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_002253.3 | chr4:g.55097758G>A | c.2518C>T | p.L840F | RefSeq | GRCh38/hg38 |
NM_002253 | chr4:g.55097758G>A | c.2518C>T | p.L840F | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
KDR L840F | colorectal cancer | resistant | Sorafenib | Preclinical - Pdx | Actionable | In a preclinical study, a metastatic colorectal cancer patient-derived xenograft (PDX) model harboring KDR (VEGFR2) L840F did not respond to treatment with Nexavar (sorafenib) (PMID: 29588308). | 29588308 |
KDR L840F | colorectal cancer | resistant | Regorafenib | Preclinical - Pdx | Actionable | In a preclinical study, a metastatic colorectal cancer patient-derived xenograft (PDX) model harboring KDR (VEGFR2) L840F did not respond to treatment with Stivarga (regorafenib) (PMID: 29588308). | 29588308 |
Molecular Profile | Protein Effect | Treatment Approaches |
---|---|---|
KDR L840F | unknown |