Gene Variant Detail

Gene KDR
Variant L840F
Impact List missense
Protein Effect unknown
Gene Variant Descriptions KDR (VEGFR2) L840F lies within the protein kinase domain of the Kdr (Vegfr2) protein (UniProt.org). The functional effect of L840F is conflicting, as it results in a loss of Kdr (Vegfr2) kinase activity in culture, but promotes tumor development in xenograft models, and is associated with resistance to Kdr (VEGFR2) inhibitors (PMID: 29588308).
Associated Drug Resistance Y

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Transcript NM_002253
gDNA chr4:g.55097758G>A
cDNA c.2518C>T
Protein p.L840F
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002253 chr4:g.55097758G>A c.2518C>T p.L840F RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
KDR L840F unknown
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KDR L840F colorectal cancer resistant Regorafenib Preclinical - Pdx Actionable In a preclinical study, a metastatic colorectal cancer patient-derived xenograft (PDX) model harboring KDR (VEGFR2) L840F did not respond to treatment with Stivarga (regorafenib) (PMID: 29588308). 29588308
KDR L840F colorectal cancer resistant Sorafenib Preclinical - Pdx Actionable In a preclinical study, a metastatic colorectal cancer patient-derived xenograft (PDX) model harboring KDR (VEGFR2) L840F did not respond to treatment with Nexavar (sorafenib) (PMID: 29588308). 29588308