Gene Variant Detail

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Gene STK11
Variant L285Lfs*2
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions STK11 L285Lfs*2 indicates a shift in the reading frame starting at amino acid 285 and terminating 2 residues downstream, causing a premature truncation of the 433 amino acid Stk11 protein (UniProt.org). L285Lfs*2 results in decreased Tp53 activity in culture and therefore, is predicted to lead to a loss of Stk11 protein function (PMID: 30092773).
Associated Drug Resistance

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Transcript NM_000455
gDNA chr19:g.(1221331_1221339)
cDNA c.(853_861)
Protein p.L285Lfs*2
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_005259617 chr19:g.(1221331_1221339) c.(853_861) p.L285Lfs*2 RefSeq GRCh38/hg38
XM_005259618 chr19:g.(1221331_1221339) c.(853_861) p.L285Lfs*2 RefSeq GRCh38/hg38
NM_000455 chr19:g.(1221331_1221339) c.(853_861) p.L285Lfs*2 RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
STK11 L285Lfs*2 loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References