Gene Variant Detail

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Gene BRAF
Variant P731T
Impact List missense
Protein Effect unknown
Gene Variant Descriptions BRAF P731T does not lie within any known functional domains of the Braf protein (UniProt.org). P731T has been identified in the scientific literature (PMID: 29320312), but has not been biochemically characterized and therefore, its effect on Braf protein function is unknown (PubMed, Nov 2022).
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF P731T

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Transcript NM_004333.5
gDNA chr7:g.140734707G>T
cDNA c.2191C>A
Protein p.P731T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004333 chr7:g.140734707G>T c.2191C>A p.P731T RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140734707G>T c.2191C>A p.P731T RefSeq GRCh38/hg38
XM_005250045 chr7:g.140734707G>T c.2191C>A p.P731T RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140734707G>T c.2191C>A p.P731T RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF P731T Advanced Solid Tumor no benefit Vemurafenib Clinical Study - Cohort Actionable In a Phase II trial (MyPathway), Zelboraf (vemurafenib) treatment resulted in an objective response in only 4% (1/23) of patient with advanced solid tumors harboring non-V600 BRAF mutations, 1 of the non-responding patients harbored BRAF P731T (PMID: 29320312; NCT02091141). 29320312