Gene Variant Detail

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Gene BRAF
Variant K601_S602delinsNT
Impact List indel
Protein Effect unknown
Gene Variant Descriptions BRAF K601_S602delinsNT results in deletion of a lysine (K) and a serine (S) in the protein kinase domain of the Braf protein from amino acids 601 to 602, combined with the insertion of an asparagine (N) and a threonine (T) at the same site (UniProt.org). K601_S602delinsNT has not been characterized in the scientific literature and therefore, its effect on Braf protein function is unknown (PubMed, Dec 2023).
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF K601_S602delinsNT

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Transcript NM_004333.6
gDNA chr7:g.140753329_140753334delinsTGTGTT
cDNA c.1801_1806delinsAACACA
Protein p.K601_S602delinsNT
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004333 chr7:g.140753329_140753334delinsTGTGTT c.1801_1806delinsAACACA p.K601_S602delinsNT RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140753329_140753334delinsTGTGTT c.1801_1806delinsAACACA p.K601_S602delinsNT RefSeq GRCh38/hg38
XM_005250045 chr7:g.140753329_140753334delinsTGTGTT c.1801_1806delinsAACACA p.K601_S602delinsNT RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140753329_140753334delinsTGTGTT c.1801_1806delinsAACACA p.K601_S602delinsNT RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140753329_140753334delinsTGTGTT c.1801_1806delinsAACACA p.K601_S602delinsNT RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140753329_140753334delinsTGTGTT c.1801_1806delinsAACACA p.K601_S602delinsNT RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140753329_140753334delinsTGTGTT c.1801_1806delinsAACACA p.K601_S602delinsNT RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140753329_140753334delinsTGTGTT c.1801_1806delinsAACACA p.K601_S602delinsNT RefSeq GRCh38/hg38

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03843775 Phase Ib/II Binimetinib + Encorafenib A Study of Binimetinib and Encorafenib in Advanced BRAF Mutant Cancers Completed USA 0