Gene Variant Detail

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Gene BRAF
Variant T599_V600insS
Impact List insertion
Protein Effect unknown
Gene Variant Descriptions BRAF T599_V600insS results in the insertion of a serine (S) in the protein kinase domain of the Braf protein between amino acids 599 and 600 (UniProt.org). T599_V600insS has not been characterized in the scientific literature and therefore, its effect on Braf protein function is unknown (PubMed, Nov 2022).
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF T599_V600insS

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Transcript NM_004333.5
gDNA chr7:g.140753337_140753338insGCT
cDNA c.1797_1798insAGC
Protein p.T599_V600insS
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001354609.1 chr7:g.140753337_140753338insGCT c.1797_1798insAGC p.T599_V600insS RefSeq GRCh38/hg38
NM_004333 chr7:g.140753337_140753338insGCT c.1797_1798insAGC p.T599_V600insS RefSeq GRCh38/hg38
XM_005250045 chr7:g.140753337_140753338insGCT c.1797_1798insAGC p.T599_V600insS RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140753337_140753338insGCT c.1797_1798insAGC p.T599_V600insS RefSeq GRCh38/hg38

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  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References