Gene Variant Detail

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Gene STK11
Variant F298L
Impact List missense
Protein Effect unknown
Gene Variant Descriptions STK11 F298L lies within the protein kinase domain of the Stk11 protein (UniProt.org). F298L has been identified in the scientific literature (PMID: 27615706), but has not been biochemically characterized and therefore, its effect on Stk11 protein function is unknown (PubMed, Mar 2020).
Associated Drug Resistance

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Transcript NM_000455
gDNA chr19:g.1221978T>C
cDNA c.892T>C
Protein p.F298L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_005259618 chr19:g.1221978T>C c.892T>C p.F298L RefSeq GRCh38/hg38
NM_000455 chr19:g.1221978T>C c.892T>C p.F298L RefSeq GRCh38/hg38
XM_005259617 chr19:g.1221978T>C c.892T>C p.F298L RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
STK11 F298L unknown
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
STK11 F298L pituitary carcinoma predicted - sensitive Everolimus + Radiotherapy Case Reports/Case Series Actionable In a clinical case study, a patient with adenocorticotropic pituitary carcinoma harboring an STK11 inactivating mutation demonstrated clinical efficacy for greater than 6 months when treated with a combination of Afinitor (everolimus) and radiotherapy (PMID: 27615706). 27615706