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|Gene Variant Descriptions||TP53 positive indicates the presence of the TP53 gene, mRNA, and/or protein.|
|Associated Drug Resistance|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|TP53 positive||ovarian cancer||predicted - sensitive||NU6027 + Temozolomide||Preclinical - Cell culture||Actionable||In a preclinical study, NU6027 enhanced the efficacy of Temodar (temozolomide) in ovarian cancer cells with mismatch repair activity and positive for TP53 in culture, demonstrating a 50% greater decrease in cell survival compared to Temodar (temozolomide) alone (PMID: 21730979).||21730979|
|TP53 positive||Advanced Solid Tumor||predicted - sensitive||p28||Phase I||Actionable||In a Phase I trial, treatment with p28 was well-tolerated and demonstrated preliminary efficacy in patients with Tp53-positive advanced solid tumors, with complete response in 6% (1/15), partial response in 20% (3/15), and stable disease in 46% (7/15) of patients (PMID: 23449360).||23449360|
|TP53 positive||Advanced Solid Tumor||sensitive||Serdemetan||Phase I||Actionable||In a Phase I trial, Serdemetan (JNJ-26854165) treatment increased Tp53 expression in tumor and surrogate tissue, resulted in partial response in 1.8% (1/57) and stable disease in 38.6% (22/57) of patients with advanced solid tumors (PMID: 21831953).||21831953|
|TP53 positive||Advanced Solid Tumor||sensitive||MVAp53||Phase I||Actionable||In a phase I study, Ankara (MVAp53) demonstrated safety and efficacy in patients with metastatic colon, gastric and pancreas cancer stained positive for p53 (J Clin Oncol 31, 2013 (suppl; abstr 3089)).||detail...|
|TP53 positive||breast cancer||sensitive||Serdemetan||Phase I||Actionable||In a Phase I trial, Serdemetan (JNJ-26854165) treatment induced a 102% increase of Tp53 expression in tumor tissue, resulted in partial response in a patient with breast cancer (PMID: 21831953).||21831953|
|Molecular Profile||Protein Effect||Treatment Approaches|