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|Variant||FGFR2 - ROCK1|
|Gene Variant Descriptions||FGFR2-ROCK1 results from the fusion of FGFR2 and ROCK1 (PMID: 30745300). FGFR2-ROCK1 has been identified in cholangiocarcinoma (PMID: 30745300), but has not been biochemically characterized and therefore, the effect on protein function is unknown (PubMed, Aug 2020).|
|Associated Drug Resistance|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|FGFR2 - ROCK1||cholangiocarcinoma||predicted - sensitive||Debio 1347||Case Reports/Case Series||Actionable||In a Phase I trial, Debio 1347 treatment resulted in stable disease in a patient with cholangiocarcinoma harboring FGFR2-ROCK1 (PMID: 30745300; NCT01948297).||30745300|
|Molecular Profile||Protein Effect||Treatment Approaches|
|FGFR2 - ROCK1||unknown|